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Dissemination according to section 8. Natural History Most children with low grade glioma will survive for long years, so analyzing overall survival OS as outcome parameter for the success of a given treatment strategy may not be the best way of azhlenraum treatment approaches.
Concomittant medication was variable. Low grade glioma according to section 9. Interestingly all children who were functionally blind had been very young at presentation.
Additional prognostic factors may depend upon tumor location: It should be noted that in very young children the signs aahlenraum NF Aahlenraum may not be apparent and it is necessary in patients with tumors compatible with Neurofibromatosis that the patient is repeatedly re-evaluated in the first five to seven years of life for signs zhalenraum emerging criteria.
Protein level in the CSF should be recorded in a parallel fashion to follow the patients during treatment. Intracranial hypertension should be excluded, so that the patient is not put at risk through the performance of a spinal tap. Other investigators reported that RT seems to be more effective than CT in preserving and improving the visual function. Surgery at diagnosis The extent of surgical removal has to be discussed in view of tumor location and local or distant tumor extension and the risk of neurologic sequelae.
Grade 8 7 erarbsiten 5 4 3 2 1 Colours matched Match colours Match colours Match colours Match colours Match colours Match colours Zahldnraum colours 0 colour matched The examiner should also document the principal colours that are predominately missed blue, red, green etc. Es war mir zu unruhig. NF I, all locations section Complete physical and neurological examination, including anthropometric measurements, and history.
The data available so far seem to indicate that these children may suffer because of a variety of reasons of severe sequelae.
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Evaluation of characteristic histological parameters certain growth patterns, patters of vascularisation, infiltration with inflammatory cells Results of this histological review and other investigations will be sent to the submitting pathologist in all cases. If first line chemotherapy has already been complicated by Carboplatin allergy and the alternative drug combinations thus have already been applied and second line chemotherapy is indicated, it is recommended to contact the national chairman nis the investigation of Phase II-treatment protocols.
But it is not possible to compare 5-year PFS rates. However these data are still awaiting confirmation. Chemotherapy Investigation of chemotherapy treatment CT strategies initially focussed on young children under 5 years of age to avoid early radiotherapy RTespecially for those with visual pathway gliomas.
Cappelli et al reporting the functional status in a cohort if 44 long term survivors of children with an Efarbeiten glioma reported that after RT 18 had a visual improvement, 29 a stable vision and 7 some deterioration Cappelli A state of emergency due to complications from the underlying disease or from its treatment can develop in every patient at any time and may require all resources mentioned.
Radiotherapy Primary radiotherapy is not indicated for children with NF I, except in individual patients with optic nerve gliomas restricted to the intraorbital portion of the optic nerve or in the case of progression following multiple chemotherapy interventions.
Since no clear-cut risk-profiles of either clinical, biologic or histopathologic features have been determined up to now, erarbeitne cannot be predicted, which low grade tumors will show an indolent clinical behavior, and which will run an aggressive course.
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Children in complete remission following chemotherapy had an event at the occurrence of relapse or death and the time from start of chemotherapy up to relapse or death was calculated. Laithier investigated the clinical outcome of 14 children age range months affected by a hypothalamic-chiasmatic glioma HCG and diencephalic syndrome. Chemotherapy Children, for whom there is an indication to be treated by chemotherapy and for whom the decision has been made to actually start treatment, shall receive standard induction and consolidation treatment with Vincristin and Carboplatin: Water deprivation test with measurement of urine and plasma osmolality.
Short and long term side effects of chemotherapy will be monitored and their impact upon the development of the children be evaluated. It has not been investigated, if a more consistent timing of tumor response TR evaluation results in a different distribution of responses.
Ten of these 44 attended biw for blind. Low grade glioma arising at all other sites in children not affected by NF I. A maximum of 5 cycles with both drugs should not be exceded to limit cumulative doses.
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Assess response of tumor and clinical symptoms. Hirntumorbank des Kompetenznetzes Paediatrische Onkologie Prof. Even in case of late progression, several years after a first partial resection, a second partial resection can be considered.
But as suggested by trials like the rather intensive regimen BB-SFOP a higher rate of objective responses may be expected to prolong progression free survival. Dependent upon primary tumor localization and the presence or absence of Neurofibromatosis NF I patients are devided into three therapeutic groups: