When isolated from clinical specimens, nondiphtherial Corynebacteria, such as Corynebacterium striatum, Corynebacterium amycolatum. ABSTRACT. We describe an unusual cluster of Corynebacterium striatum infections in 21 patients with chronic obstructive pulmonary disease (COPD) admitted. Objective: To evaluate the clinical significance of and describe factors associated with Corynebacterium striatum infection. Methods: A.

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Resistance to fluoroquinolones in Corynebacterium spp. In that cases the Corynebacterium were considered of clinical significance since they were associated with a strong leukocyte reaction in Gram staining Boltin D, et al.

Tobramycin was also very active 56 isolates were susceptible. Corynebacterium striatum is recognized as a true pathogen when isolated in several samples from sterile body sites or from indwelling medical devices 12. Therefore, daptomycin can also be considered as an alternative to vancomycin for treatment of C. Immunity in an infant population in the City of S.

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Case Reports in Infectious Diseases

The nonlipophilic bacteria may be classified as fermentative and nonfermentative:. The genus Corynebacterium was created by Lehmann and Neumann in as a taxonomic group to contain the bacterial rods responsible for causing diphtheria. Thus, the patient was diagnosed with a C.

In conclusion, although Corynebacterium could be isolated from a blood culture as a common contaminant, stdiatum certain case this observation could conceal a dangerous infection. However, the patient died on day 73 of admission. Other mechanisms such as active efflux of the antimicrobial and reduced intake into the bacterial cell can contribute to streptomycin resistance in these isolates.


This case highlights the role of C. The fact that many different antibiotic resistance profiles could be distinguished among the strains belonging to a particular PFGE pattern revealed that there was not a single strain but several closely related clones producing sporadic infections. L-Lysine production is specific to C. Gram-positive bacilli were detected in both blood culture samples; each set included aerobic and anaerobic cultures Figures 1 b and 1 corynebacrerium.

Although initial studies indicated that C. Upon antibiotic administration, a selective pressure is created in body organs where fluoroquinolones tend to accumulate.

Corynebacterium – Wikipedia

Technical University of Denmark. In vitro susceptibility tests showed that linezolid and tigecycline are active against coryneform bacteria, revealing a potential therapeutic value [ sfriatum16 ] of these compounds.

However, the occurrence of resistant strains requires continual vigilance. Erythromycin and clindamycin were inactive against the majority of our C. From the 24 clindamycin-resistant isolates 22 were positive for the gene erm X and 10 out of 22 were also erm B -positive.

Received Feb 7; Accepted Aug 4. Cystitis and haematuria due to Corynebacterium striatum. The cluster is made up of the species C.

This would eventually lead this strain to become a secondary colonizer in immunocompromised sriatum [ 8 ]. The bacteria grow in Loeffler’s mediumblood agarand stristum soy agar TSA.

This fact confirms the previously reported high prevalence of resistance to compounds of the MLS B group among Corynebacterium spp. Perhaps the most notable one is C. Table 3 Sources of specimens from whom C. Indexed in Web of Science. Thus, several outbreaks of clonal multidrug-resistant C.


Author information Article notes Copyright and License information Disclaimer. However, most of these cases are represented by patients with implanted indwelling devices or who present an immunosuppression [ 26 ]. Pathogenic species in other animals include C. National Center for Biotechnology InformationU. Outbreaks caused by multidrug-resistant C. Three of the conserved signature proteins have homologs found in the genus Dietziawhich is believed to be the closest related genus to Corynebacterium.

Corynebacterial endocarditis is seen most frequently in patients with intravascular devices. This method is based on the assessment of biochemical properties.

High frequency of macrolide resistance mechanisms in clinical isolates of Corynebacterium species. To our knowledge, this is the second report which found both blood cultures and cultures from a central venous catheter tip positive for corynebacteriumm same strain of C. Twenty-nine resistance profiles were distinguished among the 59 resistant C. Susceptibility to aminoglycosides and distribution of aph and aac 3 -XI genes among Corynebacterium corynnebacterium clinical isolates.

Linezolid can be considered as an alternative to vancomycin against C. This study was performed in accordance with the ethical guidelines of the Declaration of Helsinki Correspondence should be addressed to Ueno Daisuke ; pj. Magiorakos AP, et al.