PDF | The present study aims to evaluate the therapeutic properties of the medicinal plants (Vitex negundo, Aegle marmelos and Boswellia serrata) for their . Abstract To evaluate the anti-inflammatory activity of Vitex negundo (VN) leaf extract and its mechanism of action in experimental animals. Carrageenin induced. Abstract. The present study was undertaken to assess the anti-inflammatory effect of ethanolic extract of Vitex negundo roots in rats.

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Support Center Support Center. National Center for Biotechnology InformationU. These findings were in agreement with the findings of Telang et al. Flavonoids are an important group of polyphenols and are reported to inhibit prostaglandin synthesis, which are known mediators of inflammation International Journal of Pharmacology, 2: Proceedings of the international workshop, Lucknow: Group I of cotton granulona test receiving distilled water served as diseased control.

The whole percolate extract of V. X 7 days orally and Ibuprofen mg kg -1 B. The prostaglandins are known to play important role in genesis of sign and symptoms of acute inflammation Mocada et al. Abstract To inf,ammatory the anti-inflammatory activity of Vitex negundo VN leaf extract and its mechanism of action in experimental animals.

Moreover, leaves of VN are aactivity to possess various anti-oxidant chemical constituents like flavonoids Banerji et al. The tissue damage then provokes inflammatory response by the production of mediators and chemotactic factors 4. The extract was concentrated under vacuum.

Plasma MDA Malondialdehyde estimation: Oxytocin was dissolved in distilled water to get a desired concentration. VN extract was administered orally in graded dosesand mg kg -1 as single dose therapy and twice daily for 7 day in respective inflammatory experimental models.

Procedure Thirty minutes after drug or test compound extracts administration, 0. Ferrous sulphate, ascorbic acid, sodium chloride, potassium chloride, all of LR grade were obtained from local suppliers.


In cotton pellet granuloma test VN extract in graded dosesand mg kg The filtrates were kept on water bath to obtain the crude extract [ 10 ]. Studies on analgesic and anti-inflammatory activities of Vitex negundo Linn.

Khare CP Indian medicinal plants an illustrated dictionary.

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The plant material was collected from Versova, Mumbai and plant sample was authenticated from Blatter Herbarium, St. CDepartment of Biochemistry, for allowing us to perform bio-chemical investigation in the department. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. We also extend our sincere thanks to Dr.

Group I received distilled water and served as control. The results strongly suggest that radical quenching may be one of the mechanisms responsible for its antiinflammatory activity.

The mechanism of anti-inflammatory action was explored by observing its effect on oxytocin induced contractions in rat uterus and oxidative stress. I method of assay and effects of storage.

The plant material and preparation of extract: Indian Council of Medical Research India 2: These observations suggest that VN possesses anti-inflammatory activity against acute as well as sub-acute inflammation, which appear to be due to prostaglandin inhibition and reduction of oxidative stress respectively, which needs to be substantiated by further study.

Abstract Reactive oxygen species are implicated in various inflammatory disorders. Used by Meir et al.

The ethno medical use of V. Statistical analysis was carried out by applying student’s t-test. The animals were fasted overnight before the experiment. Diclofenac sodium was obtained from Mac Labs, Mumbai as a gift sample.

It was identified and authenticated by an expert botanist from J.

Antioxidant and Antiinflammatory Activity of Vitex negundo.

The same procedure was repeated at 30 min 1, 2, 3 h. The anti-inflammatory activity in this dose of the test drug was comparable to phenylbutazone mg kg -1 PO. In the method studied for mechanism of anti-inflammatory activity, against acute inflammation, the VN extract in different dose concentration 0. Wiley Series Chemistry and Pharmacology of Drugs. Inhibitory effect of Vitex-negundo extract on oxytocin induced contractions in rat uterus in a dose dependant manner.


The basic literature survey exposed that Vitex negundo hasantioxidant, antiulcer and anti-nociceptive activity and Murraya koenigii possessing anthelmintic, analgesic, cooling activity, but not many scientific studies have been carried out to reveal and collaborate the anti-inflammatory activity of Vitex negundo and Murraya koenigii leaves.

Albino rats of either sex were divided into five groups of six animals each. Steam distillate of the leaves can be used as stomachic, purgative, febrifuge and antiemetic [ 8 ].

Extracts were prepared in bitex to study their anti-inflammatory activity. Footnotes Neyundo, et al.: The difference in wet and dry weights of activuty from control group to that of treated group indicates the anti-inflammatory activity. Anti-inflammatory effect of Vitex negundo extract in albino rats By cotton pellet granuloma method.

These observations suggest VN to possess anti-inflammatory activity against acute as well as sub-acute inflammation which appears probably to be due to prostaglandin inhibition and reduction of oxidative stress respectively. Hence the extract was standardized in terms of total polyphenol content and found to contain After 7 days drug treatment in cotton pellet granuloma method, mL of blood was collected from inner canthus of eye from each animal using capillary tube, in a vial containing EDTA as an anticoagulant.