Amitraz intake is rarely lethal and management is symptomatic. Lack of a specific antidote and management protocols for amitraz intoxication, leave only the. Amitraz poisoning is fairly uncommon in humans and occurs via oral, dermal or inhalational routes. Only a limited number of case reports of. Other frequently occurring symptoms after massive amitraz intoxication are CNS depression, respiratory depression, miosis.
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Incidence of poisoning in Rafsanjan, Iran.
Although the effects of activated amjtraz and cathartics have not been studied, they may still be considered for treatment 1. United States Environmental Protection Agency. With the supportive management, the prognosis is good and the patients may be discharged healthy without any organ dysfunction. The role ;oisoning decontamination methods, namely, gastric lavage and activated charcoal was unclear.
Indian Pediatr ; Williams and Wilkins; In this study, we discuss the clinical features, laboratory findings, and management of 23 adults with amitraz poisoning cared for in our center. An unusual poisoning with the unusual pesticide amitraz. Levels of blood urea, creatinine, and sodium and potassium usually do not change in this poisoning, which is consistent with our observation.
A limited number of human intoxication cases have been reported in the literature with distribution of cases poisoninng worldwide.
Sax’s Dangerous Properties of Industrial Materials. An empty bottle of pesticide amitraz The amitraz- octopamine receptor interaction restrains these normal functions of the amittaz receptor.
Using atropine for treatment of bradycardia is controversial 1poisoninng8 Atropine is useful for treating hemodynamically unstable bradycardia. We report a case of a patient presenting after ten hours of poison ingestion with unconsciousness, miosis and persistent bradycardia, the most frequently reported symptoms associated with this type of poisoning.
CASE REPORT – Amitraz: An unusual poisoning
Ages ranged from 16 and 78 years mean Vet Hum Toxicol ; Since its discovery by Boots Co. The original search yielded articles, of which 52 articles described human cases. Can J Physiol Pharmacol ; Amitraz depresses cardiovascular responses to bilateral carotid occlusion. Journal of Agricultural and Food Chemistry.
Articles published in a language other than English, abstracts and those not providing sufficient clinical information were excluded. Introduction Amitraz is a triazapentadiene compound, a member of the amidine chemical family 1.
Six human cases of amitraz poisoning. Prostaglandin synthesis inhibited by formamidine pesticides. Toxicol Rev poisonibg Basic Clin Pharmacol Toxicol ; Articles from Iranian Journal of Pharmaceutical Research: Amitraz poisoning and olfaction. Amitraz is a formamidine pesticide widely used in agriculture and veterinary medicine as an amitras and acaricide. The clinical presentations of our case were relatively severe and required intubation and mechanical ventilation.
This systematic review provides information on the epidemiology, toxicokinetics, mechanisms of toxicity, clinical features, diagnosis and management of amitraz poisoning. The following day at 5: Therefore, they are considered as two of the major metabolites in the amitraz pathway. Indian J Pediatr Apr;80 4: Intensive Care Med ; Author information Article notes Copyright and License information Disclaimer.
CASE REPORT – Amitraz: An unusual poisoning – Anaesthesia, Pain & Intensive Care
Presence of coma, absence of light amutraz, and respiratory failure are probably due to the ingestion of a greater amount of amitraz, which supports its dose-dependent effects on body systems. Amitraz is a member of formamidine family of pesticides. The free -NH groups of these molecules react with each other to finally yield amitraz.
Despite a life threatening clinical picture, amitraz poisoning in humans carries a low mortality when appropriate supportive therapy is given. Middle East J Fam Med ; 4: Chemical aspects of a new group of pesticides. aamitraz
Acute amitraz poisoning in adults: clinical features, laboratory findings, and management.
In our study atropine was used before reaching amjtraz to treat bradycardia. In plants the biotransformation of amitraz proceeds very rapidly. A limited number of human intoxication cases have been published in the literature. Jacob J, Schaeffer TH.